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Individuals with certain medical conditions should avoid wearing knee-high compression stockings. These include those with peripheral artery disease, severe peripheral neuropathy, skin infections or conditions affecting the legs, and those with severe congestive heart failure. It is important for individuals to consult with a healthcare provider before using compression stockings to ensure they are appropriate for their specific health needs.

Knee-high compression stockings are generally used to prevent blood clots, not cause them. They work by applying pressure to the legs, which helps improve blood flow and reduce the risk of clot formation. However, if they are not fitted properly or are too tight, they could potentially cause circulation issues. It is important to ensure that the stockings are the correct size and are worn as directed by a healthcare professional.