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The safety information below outlines crucial warnings concerning the use of anagrelide (Agrylin). Please review these carefully and consult your healthcare provider if you have any concerns or questions.

• Heart Concerns: Anagrelide (Agrylin) may lead to heart complications, including changes in heartbeat, particularly in individuals with a history of heart issues or those at greater risk. The likelihood of such problems increases in the presence of severe liver conditions, which can elevate anagrelide levels in the body. Discuss your heart health, liver condition, and all current medications with your healthcare provider. Increased risk factors include a history of heart problems, prolonged QT interval, liver issues, and low potassium levels.

• Bleeding Risks: The combination of anagrelide (Agrylin) with aspirin could significantly increase the risk of severe bleeding. This risk is further heightened if you are on other medications that also elevate bleeding risk. It is vital to inform your healthcare provider about all medications you are using to identify possible interactions. Be vigilant for symptoms of bleeding, such as expanding bruises, bleeding gums, dark stools, or blood in the urine, and contact your provider immediately if these occur. Risk factors include the use of anagrelide with medications like aspirin, anticoagulants, NSAIDs, antiplatelet agents, and certain antidepressants.

• Respiratory Issues: Serious lung conditions have been associated with anagrelide (Agrylin) at any point during treatment. Report any new or worsening breathing difficulties, including shortness of breath, to your healthcare provider. If lung damage is suspected, discontinuation of the medication may be necessary, which can help alleviate symptoms.

Always maintain open communication with your healthcare provider to ensure the safe use of anagrelide (Agrylin).

When taking this medication, some individuals may experience common side effects such as headache, diarrhea, weakness, and nausea. Though often mild, these symptoms can include gas, dizziness, and loss of appetite. It's important to note that many people using this medication do not encounter serious side effects. To minimize dizziness, try standing up slowly from sitting or lying positions.

However, be vigilant for more serious side effects, which require prompt medical attention. These include unusual bruising or bleeding, black stools, swelling of the ankles or feet, and rapid or difficult breathing. Stomach pain, unusual tiredness, signs of kidney problems (such as changes in urine), and vomit resembling coffee grounds are also concerning.

Rare, yet very serious side effects necessitate immediate medical intervention. These include chest pain, confusion, severe dizziness, fainting, irregular heartbeat, seizures, trouble speaking, vision changes, and weakness on one side of the body. An allergic reaction, though rare, can manifest as a rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing. Seek medical help right away if these occur. Remember, this is not an exhaustive list of side effects, and contacting your healthcare provider for any unusual symptoms is always advisable.

Anagrelide (Agrylin) can interact with a variety of medications and products. It's crucial to inform your doctor and pharmacist about any medications, supplements, or vitamins you are taking. Some interactions can significantly impact your health.

Bleeding Risk: Anagrelide may increase the risk of bleeding, especially when taken with blood thinners like Warfarin, Enoxaparin, or antiplatelet drugs such as Clopidogrel. Similarly, taking Aspirin with anagrelide can elevate bleeding risk. However, if your doctor has advised you to take low-dose aspirin for heart protection, continue doing so unless directed otherwise by your healthcare provider.

Heart Rhythm Concerns (QT Prolongation): Anagrelide can affect heart rhythm, known as QT prolongation. Medicines such as Amiodarone, chloroquine, Clarithromycin, disopyramide, Haloperidol, methadone, and Moxifloxacin can also prolong QT interval. Combining these with anagrelide might increase the risk of heart rhythm issues.

Other Significant Drug Interactions: Anagrelide should be used cautiously with a broad range of medications, as interactions may require dose adjustments or careful monitoring. These include but are not limited to certain antipsychotics (e.g., Pimozide), antibiotics, and other cardiovascular and psychiatric medications.

Discuss all potential interactions with your healthcare provider to ensure safe and effective use of anagrelide.