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This medication comes with important safety considerations that you should be aware of. Please read these warnings thoroughly and discuss any concerns with your healthcare provider.

• Hormone Concerns and Withdrawal: Long-term use of hydrocortisone (Anusol-HC) rectally may lead to adrenal suppression, where your body reduces its natural production of steroid hormones. Abruptly discontinuing the medication can result in withdrawal symptoms such as dizziness, fatigue, and nausea. To avoid adrenal suppression, your healthcare provider might conduct a rectal examination to confirm that this treatment is suitable for you. Do not stop using hydrocortisone (Anusol-HC) without consulting your healthcare provider. Key risk factors include prolonged use, excessive dosage, covering the treated area with a bandage, and use in young children.

• Increased Risk of Skin Infections: Prolonged use of hydrocortisone (Anusol-HC) can heighten the risk of bacterial or fungal skin infections. Avoid using this medication if you have a skin infection, as it may exacerbate the condition. Contact your healthcare provider if you experience symptoms such as redness, swelling, pain, pus, or if your symptoms do not improve after seven days, as these may indicate a new infection.

• Skin Reactions: Extended use of hydrocortisone (Anusol-HC) beyond the prescribed duration can lead to skin irritation, including thinning, stretch marks, spider veins, burning, itching, dryness, inflamed hair follicles, changes in skin color, or rashes. To mitigate severe skin reactions, your healthcare provider may conduct a rectal exam to ensure this medication is appropriate for you. Report any new or worsening skin issues to your provider immediately. This risk is heightened with excessive or inappropriate use of the medication.

In summary, adhere to your healthcare provider's guidance and monitor for any adverse effects or changes during treatment with hydrocortisone (Anusol-HC).

When using this medication, some individuals may experience mild side effects such as burning, itching, dryness, and skin irritation. These are generally temporary, but if they persist or worsen, it's advisable to consult a healthcare provider. Additional mild reactions can include inflamed hair follicles, acne-like bumps, changes in skin color, rash, thinning skin, stretch marks, or increased hair growth in the affected area. While these effects can be bothersome, they are not typically serious.

In rare cases, more severe side effects can occur, necessitating immediate medical attention. These include new or persistent rectal bleeding, unusual bruising or bleeding, symptoms indicative of stomach or intestinal bleeding such as stomach pain or black stools, and mental or mood changes like depression or agitation. Muscle weakness, irregular heartbeat, and signs of infection, such as a persistent sore throat or fever, should also be promptly addressed.

There is a possibility, albeit rare, for this medication to be absorbed into the bloodstream, leading to systemic side effects, particularly in children or long-term users. These symptoms might include extreme tiredness, weight loss, headache, swelling of the ankles or feet, increased thirst or urination, and vision problems. If any of these occur, seek medical advice without delay.

Severe allergic reactions to this medication are very rare but require urgent medical care if symptoms such as a rash, significant swelling, severe dizziness, or difficulty breathing occur. Always stay vigilant and consult a healthcare professional if you experience any concerning symptoms.