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This safety information outlines critical warnings and precautions associated with the use of alprostadil injection. Please read carefully and discuss any concerns with your healthcare provider.

• Prolonged Erection (Priapism): Seek immediate medical attention if an erection persists for over 4 hours, as this can lead to irreversible damage to the penis. Those with conditions like sickle cell anemia, multiple myeloma, or leukemia are at increased risk. Your healthcare provider will prescribe the lowest effective dose to prevent prolonged erections and will reassess your dosage every three months. Do not alter your dose without consulting your provider.

• Penile Scarring: Although rare, prolonged use of alprostadil injection may result in penile scarring and curvature. Regular physical exams will be conducted by your provider to check for scarring. Discontinuation of the medication will be advised if scarring is detected.

• Low Blood Pressure: Alprostadil injection may cause low blood pressure, leading to dizziness, lightheadedness, or fainting. If you experience these symptoms, sit down immediately to prevent falls. Those taking other blood pressure-lowering medications should exercise caution.

• Bleeding at the Injection Site: Minor bleeding can occur at the injection site, especially if you are on blood thinners or have a bleeding disorder. Apply pressure with a sterile gauze or alcohol swab for five minutes post-injection. Discuss the risks with your healthcare provider if you are on blood thinners.

• Heart Problems from Sexual Activity: Alprostadil injection is not recommended if you have been advised against sexual activity due to heart issues. Report any symptoms like chest pain or dizziness to your healthcare provider promptly.

• Needle Breakage: The injection requires a thin needle, which can break if not used correctly. Ensure you understand the injection procedure and seek guidance from your provider or pharmacist if needed.

• Not for Children: Caverject and Caverject Impulse contain benzyl alcohol, which can cause severe and potentially fatal side effects in children. These forms should never be used in children. Prostin VR may be used in hospitals for newborns with specific heart conditions.

• Sexually Transmitted Infections (STIs): Alprostadil injection does not offer protection against STIs, including HIV. Use condoms, get regular STI testing, and limit your number of sexual partners. Female partners of childbearing age should consider birth control methods.

Contraindications:

• Avoid use if you have conditions that contribute to prolonged erections, such as sickle cell anemia, leukemia, or multiple myeloma.
• Do not use if you have an abnormally formed penis or suffer from Peyronie's disease.
• Men with penile implants should not use this medication.

Consult your healthcare provider for more information or if any of these conditions apply to you.

When using this medication, some individuals may experience mild to moderate pain, irritation, or slight bleeding at the injection site. These symptoms are generally minor, but if they persist or worsen, it's important to consult your healthcare provider. Additionally, penile pain is relatively common, occurring in some users.

There are other side effects that have been reported, such as bleeding or bruising at the injection site, penile curvature, or the development of scar tissue in the penis. Blood pooling (hematoma) at or near the injection site is also possible. While these effects may cause concern, they are not always serious unless they persist or become severe.

However, it is crucial to be aware of rare but severe side effects. These include a painful or prolonged erection lasting 4 or more hours, which requires immediate medical attention to prevent permanent damage. Additionally, if you experience symptoms such as redness, tenderness, or swelling of the penis, or any heart-related issues like chest pain, dizziness, or nausea, seek urgent medical care.

A very serious allergic reaction to this medication is rare. Nonetheless, if you notice signs such as a rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing, you should get medical help immediately. If you encounter any other side effects, not mentioned here, it is advisable to contact your healthcare provider.