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The following safety and warning information is crucial for understanding the risks and precautions associated with the use of cefazolin (Ancef). It is essential to thoroughly review this information and discuss any concerns with your healthcare provider.

• Allergic Reactions: Inform your healthcare provider if you have previously experienced allergic reactions to penicillin-type or cephalosporin antibiotics, as cefazolin (Ancef) can trigger similar allergic responses. If an allergic reaction occurs, such as difficulty breathing or swelling of the face and neck, seek immediate medical attention. Individuals with a history of such allergies may need alternative antibiotics.

• C. difficile Infection Risk: Use of cefazolin (Ancef) may, in rare cases, lead to a severe bacterial infection that causes intense diarrhea, known as a Clostridioides difficile (C. diff) infection. Risks are heightened by prolonged antibiotic use, recent antibiotic treatment, or existing stomach issues.

• Development of Drug-Resistant Bacteria: Cefazolin (Ancef) should only be used for treating bacterial infections. Misuse or overuse can result in drug-resistant bacterial infections, which are more challenging to treat. Notify your healthcare provider if you develop new symptoms or if existing symptoms persist. Risks are associated with using cefazolin (Ancef) for non-bacterial infections or for extended periods.

• Kidney Health Considerations: Cefazolin (Ancef) is eliminated by the kidneys, and impaired kidney function can lead to drug accumulation, increasing the risk of side effects like seizures. Patients with kidney problems or older adults may require dosage adjustments based on kidney function tests. Ensure your healthcare provider is informed about any kidney-related health issues.

• Contraindications: Do not use cefazolin (Ancef) if you have an allergy to cephalosporin antibiotics, as it may lead to serious health complications. Always consult with your healthcare provider before starting this medication if this condition applies to you.

By understanding these risks and taking necessary precautions, you can use cefazolin (Ancef) safely and effectively.

Common side effects:

• mild swelling at the injection site
• redness at the injection site
• pain at the injection site
• soreness at the injection site
• loss of appetite
• nausea
• vomiting
• diarrhea
• headaches
• stomach cramps

Less common but important to monitor:

• oral thrush
• new vaginal yeast infection
• mild itching
• rash

Serious side effects:

• dark urine
• easy bruising or bleeding
• fast or irregular heartbeat
• seizures
• unusual weakness
• yellowing of the eyes or skin
• mental changes like confusion
• persistent diarrhea
• severe stomach pain
• blood or mucus in stools
• serious allergic reaction
• severe dizziness
• trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Cholera Vaccine, Live

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Warfarin