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The use of Evenity (romosozumab) comes with significant safety warnings and precautions. It is crucial to understand these in order to minimize potential risks and ensure safe use of the medication. Below are the key safety points to consider:

• Heart-related Risks: This medication has been associated with an increased risk of heart attack, stroke, or heart-related death, especially in postmenopausal women compared to those using alendronate. You should not use Evenity if you have had a heart attack or stroke in the past year. Discuss with your healthcare provider if you have other risk factors such as high blood pressure, high cholesterol, diabetes, obesity, or if you smoke. Be vigilant for heart attack symptoms like chest pain, shortness of breath, or dizziness, as well as stroke signs such as headache, vision changes, difficulty speaking, or muscle weakness. Seek immediate medical attention if these occur.

• Low Blood Calcium (Hypocalcemia): Patients may experience low calcium levels, particularly those with kidney damage or undergoing dialysis. Symptoms such as muscle pain, cramps, and numbness should be promptly addressed. Regular blood tests to monitor calcium levels are advised, and calcium and vitamin D supplements are recommended.

• Jawbone Health (Osteonecrosis): Instances of jawbone breakdown have been reported. Good oral hygiene is essential, and a dental examination is advised before starting treatment. Inform your healthcare provider about any dental procedures and ensure your dentist is aware you are taking Evenity. Symptoms to watch for include jaw pain, swelling, or exposed bone.

• Thigh Fractures: There is a risk of thigh fractures, especially in individuals over 65, those with low body weight, early menopause, or a history of fracture. Be alert to any unusual hip, thigh, or groin pain and report it to your healthcare provider.

Contraindications:

• Avoid using this medication if you have low calcium levels (hypocalcemia).

In the event of an overdose or if you experience any severe side effects, seek emergency medical assistance immediately. Always consult with your healthcare provider before starting or stopping the medication, especially if you have pre-existing health conditions or are taking other medications.

When taking this medication, some individuals may experience common side effects such as joint pain, occurring in 8% to 13% of users, and headaches, reported by 5% to 7%. These effects are generally mild, but if they persist or worsen, consulting a healthcare provider is advisable for reassurance and guidance.

Other side effects that have been noted include swelling in the arms or legs, neck pain, difficulties with sleep, tingling or burning sensations, muscle spasms, and weakness. While these side effects might be uncomfortable, they are typically manageable with appropriate care.

On a more serious note, rare but severe side effects require immediate medical attention. These include symptoms of a heart attack, such as chest pain, shortness of breath, and dizziness, or signs of a stroke, like headaches, vision changes, loss of balance, or unilateral weakness or numbness. Additionally, any allergic reactions presenting as hives, rash, facial swelling, or breathing difficulties should be treated as emergencies. Furthermore, if you experience dull or aching pain in the thigh, hip, or groin, it could indicate a fracture, necessitating urgent evaluation. Always seek prompt medical care for these serious conditions.