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When taking this medication, you may experience some common side effects such as drowsiness, dizziness, headache, nausea, vomiting, loss of appetite, constipation, stomach discomfort, blurred vision, decreased coordination, or dryness in the mouth, nose, or throat. These effects typically lessen as your body gets used to the medication. If they persist or worsen, it is important to consult your healthcare provider promptly. To minimize dizziness or lightheadedness, rise slowly from sitting or lying down positions. For dry mouth relief, consider sucking on sugarless candy or ice chips, chewing sugarless gum, drinking water, or using a saliva substitute.

Triprolidine may also cause mucus in the lungs to become thicker and more difficult to clear, potentially affecting breathing. Drinking plenty of fluids can help mitigate this effect, unless advised otherwise by your healthcare provider. Serious side effects, although uncommon, should be reported immediately to your healthcare provider. These include mental or mood changes like hallucinations or irritability, ringing in the ears, difficulty urinating, easy bruising or bleeding, irregular heartbeat, and seizures.

Severe allergic reactions to this medication are rare but require urgent medical attention if symptoms such as rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing occur. This list does not cover all possible side effects, so if you notice any other unusual symptoms, contact your healthcare provider for advice.