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The following safety information outlines crucial warnings associated with the use of ketamine (Ketalar). It is important to understand these risks and take necessary precautions. Consult your healthcare provider for further guidance.

• Vital Signs Monitoring: Ketamine may cause temporary changes in blood pressure and heart rate, potentially leading to irregular heartbeat and other cardiac issues. Healthcare providers will monitor vital signs and heart activity during ketamine administration.

• Post-Wakening Reactions: After waking from surgery or a procedure involving ketamine, some individuals may experience confusion, distress, or hallucinations. These effects can include feeling as if in a dream-like state, resulting in excitement or illogical behavior. The duration of these reactions varies based on dosage and administration method. To mitigate these effects, additional medications may be administered, or a quiet environment may be provided upon awakening.

• Respiratory Concerns: Administering ketamine in excessive amounts or too rapidly can lead to breathing difficulties. Medical professionals will oversee breathing and oxygen levels, adjusting dosages as necessary to avoid such complications.

• Risks for Newborns and Children: The safety of ketamine for pregnant women, unborn babies, and children under 16 remains uncertain. The necessity of anesthesia for specific procedures should be weighed against potential risks. Discuss the safety of ketamine with your healthcare provider concerning its use in children.

• Liver Health: Repeated use of ketamine may increase the risk of liver problems. Liver function will be monitored if frequent or repeated administration is required.

• Drug Interactions: Ketamine can interact with other medications. Disclose all current medications to your healthcare provider prior to surgery or procedures. Combining ketamine with theophylline or aminophylline may increase seizure risk. Additionally, combining ketamine with central nervous system depressants like opioids, benzodiazepines, or alcohol can result in excessive drowsiness, respiratory issues, coma, or death. Your provider might adjust dosages and closely monitor you to ensure safe usage.

Always inform your healthcare provider of any medications you are taking and adhere to their guidance to ensure safe use of ketamine.