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It is important to be aware of the potential risks and necessary precautions associated with the use of Vyvanse (lisdexamfetamine), an amphetamine-type medication. This information is crucial for both patients and healthcare providers to ensure safe and effective use. Please review the following details carefully:

• Misuse and Dependence: Vyvanse can be habit-forming and has a risk of misuse, especially if not used as prescribed. Misuse can lead to severe side effects such as increased heart rate, elevated blood pressure, aggressive behavior, and harmful thoughts. Individuals with a history of substance or alcohol use disorder are at a higher risk. Dependency may develop with long-term use, leading to withdrawal symptoms if suddenly stopped. Consult your healthcare provider for guidance.

• Serious Cardiac Issues: There is a risk of serious heart-related events, including sudden death, stroke, and heart attack, even at recommended doses. Vyvanse can increase blood pressure and heart rate. Inform your healthcare provider of any pre-existing heart conditions before starting the medication, and report any symptoms like fainting, chest pain during physical activity, or irregular heartbeat immediately.

• Behavioral and Mental Health Changes: Some users may experience changes in behavior or mental health, such as hallucinations, unclear thinking, or mania. These symptoms can occur even in individuals without a prior history of such issues. If these symptoms arise, contact your healthcare provider immediately.

• Impact on Children's Growth: Vyvanse may slow growth in children, affecting both height and weight. Regular monitoring of the child's growth by a healthcare provider is recommended. If growth issues are suspected, treatment may need to be adjusted.

• Blood Circulation Issues: Vyvanse can cause problems with blood circulation, such as Raynaud's phenomenon, affecting the fingers and toes. Symptoms include color changes, coldness, numbness, or pain. Inform your provider if these occur.

• Serotonin Syndrome Risk: There is a rare but serious risk of serotonin syndrome, especially when combined with medications that affect serotonin levels, like certain antidepressants, MAOIs, and migraine medications. Symptoms include rapid heart rate, sweating, muscle stiffness, high fever, and confusion. Seek immediate medical attention if these occur.

• Drug Interactions: Vyvanse can interact with various medications, increasing the risk of side effects. Avoid using with MAOIs and certain heartburn products. Discuss all current medications with your healthcare provider to manage potential interactions effectively.

• Contraindications: Vyvanse should not be used if you have a severe allergy to amphetamines or if you are currently taking or have recently taken MAOIs or other specified medications. Consult your healthcare provider if these conditions apply.

By adhering to these guidelines and maintaining open communication with your healthcare provider, you can help ensure the safe use of Vyvanse.

Common side effects:

• Loss of appetite
• Difficulty sleeping
• Dry mouth
• Stomach or abdominal pain
• Irritability
• Nervousness
• Nausea
• Vomiting
• Constipation
• Headache
• Dizziness
• Sweating
• Weight loss
• Restlessness

Less common but important to monitor:

• Increased blood pressure
• Blurred vision
• Irregular or fast heartbeat
• Uncontrolled movements or muscle twitching
• Extreme tiredness
• Mood or behavior changes (agitation, aggression, depression, mood swings, hallucinations, thoughts of self-harm)
• Coldness, numbness, or pain in fingers or toes
• Changes in sexual interest or ability
• Swelling of ankles or feet
• Rapid, unexplained weight loss

Serious side effects:

• Chest pain
• Shortness of breath
• Fainting
• Seizures
• Sudden weakness on one side of the body
• Trouble speaking
• Confusion
• Sudden vision changes
• Severe allergic reactions (rash, swelling especially of face/tongue/throat, severe dizziness, trouble breathing)
• Serotonin syndrome (fast heartbeat, severe dizziness, loss of coordination, unexplained fever, agitation, confusion, hallucinations, severe nausea or vomiting, muscle twitching, diarrhea)

Interactions with high risk of serious adverse effects and should be avoided:

• Monoamine oxidase inhibitors (MAOIs) such as phenelzine, Selegiline, Tranylcypromine (risk of dangerous increases in blood pressure)
• Medications that affect serotonin levels such as SSRIs, SNRIs, Linezolid, Methylene Blue (risk of serotonin syndrome)
• Alcohol (may increase side effects or cause unpredictable reactions)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Decongestants (drugs that increase blood pressure or heart rate; may strengthen these effects)
• Asthma medications (drugs that increase blood pressure or heart rate; may strengthen these effects)
• Acidifying agents (such as Vitamin C; can affect removal of lisdexamfetamine)
• Alkalinizing agents (such as Sodium Bicarbonate; can affect removal of lisdexamfetamine)

Interactions with low risk that usually do not require a change in therapy:

• Mineral supplements (may sometimes affect absorption and effectiveness)