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When taking this medication, you might experience some common side effects such as dizziness, drowsiness, nausea, and vomiting. These effects are generally mild, but if they persist or worsen, it's important to consult with a healthcare professional for guidance. For most individuals, the benefits of the medication outweigh these mild inconveniences, and serious side effects are rare.

However, it is crucial to be aware of the signs of a serious allergic reaction, which, although uncommon, require immediate medical attention. These signs include a rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, and difficulty breathing.

While this summary covers many of the potential side effects, it's not exhaustive. If you experience any unexpected symptoms while using this medication, reaching out to a healthcare provider is advisable to ensure your safety and well-being.

Avoid using certain MAO inhibitors with this medication, as it may cause a severe, potentially fatal interaction. Do not take isocarboxazid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, or Tranylcypromine while using this medicine. Additionally, most MAO inhibitors should not be taken for two weeks before starting treatment with this drug. Please consult your doctor for guidance on when to begin or discontinue use. Rolapitant is another product that may interact with this medication.

Guaifenesin and dextromethorphan are available in both prescription and over-the-counter forms. Carefully read all medication labels to ensure you are not consuming more than one product containing either guaifenesin or dextromethorphan.

Guaifenesin may affect certain laboratory tests, such as those measuring urine levels of specific acids, potentially leading to inaccurate results. Inform lab personnel and all your healthcare providers that you are using this medication.