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The safety and warning information regarding Orphengesic Forte is crucial for ensuring safe use of the medication. Please pay close attention to the following points and discuss any concerns with your healthcare provider:

• Stomach Issues: Orphengesic Forte can cause irritation, bleeding, or ulcers in the stomach or intestines, presenting symptoms such as stomach pain or heartburn. The risk increases if you're using blood thinners (e.g., warfarin) or oral corticosteroids. Seek immediate medical attention if you experience persistent stomach pain, vomit blood or material that resembles coffee grounds, or have bloody or black stools. Individuals with a history of stomach bleeding or ulcers, bleeding disorders, concurrent use of NSAIDs, blood thinners, or corticosteroids, alcohol use, those aged 60 or older, long-term users, or those taking higher doses are at greater risk.

• Pregnancy Concerns: Orphengesic Forte may harm an unborn baby when taken at 20 weeks of pregnancy or later. It can affect the baby's kidneys and amniotic fluid levels, and from 30 weeks onward, it may cause heart defects. Pregnant individuals should consult their healthcare provider to explore safer alternatives.

• Severe Allergic or Skin Reactions: Although rare, severe allergic or skin reactions can occur, characterized by fever, facial swelling, redness or peeling skin, painful rashes, or fluid-filled blisters. Discontinue use and seek emergency medical care if these symptoms appear.

In addition to the warnings, certain conditions contraindicate the use of Orphengesic Forte, meaning it should not be used under these circumstances:

• Presence of glaucoma
• Any blockage in the stomach, intestines, or other parts of the digestive system
• An enlarged prostate or bladder issues
• Myasthenia gravis, a condition affecting nerves and muscles
• Severe allergic reactions to aspirin or other NSAIDs
• Sensitivity to caffeine

For any of these conditions, consult your healthcare provider before taking Orphengesic Forte to avoid serious health risks.

Common side effects:

• Dry mouth
• Dizziness
• Drowsiness
• Lightheadedness
• Blurred vision
• Headache
• Upset stomach
• Heartburn
• Nausea
• Vomiting
• Constipation
• Trouble sleeping

Serious side effects:

• Mental or mood changes (confusion, anxiety, hallucinations, nervousness)
• Shaking
• Fast or irregular heartbeat
• Difficulty hearing
• Trouble urinating
• Easy bruising or bleeding
• Fainting
• Eye pain
• Unusual tiredness
• Signs of kidney problems (changes in urination)
• Stomach or intestinal bleeding (persistent stomach pain, black stools, vomit resembling coffee grounds)
• Allergic reactions (fever, swollen lymph nodes, rash, itching or swelling, severe dizziness, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• clopidogrel
• dabigatran
• enoxaparin
• warfarin

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• dichlorphenamide
• methotrexate
• mifepristone
• vemurafenib
• ibuprofen
• ketorolac
• naproxen
• codeine
• hydrocodone
• alprazolam
• lorazepam
• zolpidem
• carisoprodol
• cyclobenzaprine
• cetirizine
• diphenhydramine