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When taking this medication, you might experience mild side effects such as nausea, vomiting, diarrhea, or stomach pain, which can often be minimized by taking the medication after meals. Occasionally, you may notice an empty tablet shell in your stool; this is harmless and indicates the medication has been absorbed.

In some cases, serious stomach or intestinal problems could occur, including bleeding, blockage, or puncture. Immediate medical attention is necessary if you experience symptoms such as abdominal swelling, black or bloody stools, constipation, dizziness, a fast heartbeat, severe stomach or abdominal pain, difficulty swallowing, severe vomiting, or vomit resembling coffee grounds.

This medication may also lead to elevated potassium levels in the blood, known as hyperkalemia. Serious symptoms requiring immediate medical attention include muscle cramps or weakness, severe dizziness, a slow or irregular heartbeat, mental or mood changes like confusion or restlessness, tingling in the hands or feet, and unusually cold skin.

Although rare, severe allergic reactions can occur. Seek emergency medical help if you notice signs such as a rash, itching, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing. This summary does not cover all possible side effects, so if you experience any unusual symptoms, contact your healthcare provider for advice.

Certain medications may interact with this drug. These include:

• Antacids containing aluminum
• Aspirin and other salicylates, like salsalate
• Blood pressure medications, such as ACE inhibitors (e.g., lisinopril) and angiotensin blockers (e.g., losartan)
• Drospirenone
• Medications that reduce food or drug movement through the esophagus or stomach, such as anticholinergics (e.g., belladonna, scopolamine, benztropine), antispasmodics (e.g., glycopyrrolate, oxybutynin), and strong opioid pain relievers like morphine
• Eplerenone
• Certain heart medications, including quinidine and digoxin
• Lithium
• Potassium supplements and salt substitutes
• Pramlintide
• Water pills that are potassium-sparing diuretics, like amiloride, spironolactone, and triamterene

If your doctor has instructed you to take low-dose aspirin (typically 81-162 milligrams daily) to prevent heart attack or stroke, continue taking it unless advised otherwise by your doctor. For more details, consult your doctor or pharmacist.