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The safety and warning information for Xermelo (telotristat ethyl) is crucial for ensuring safe usage and minimizing risks. Below are the key points you should be aware of:

• Severe Constipation Risk: Xermelo (telotristat ethyl) may reduce the frequency of bowel movements, potentially causing constipation. Severe constipation can lead to serious gastrointestinal issues that may be life-threatening. If you experience severe constipation or persistent, worsening abdominal pain, discontinue the medication immediately and consult your healthcare provider.

• Consultation Recommended: Always discuss any concerns with your healthcare provider to ensure safe use of the medication.

Please note that there are no specific contraindications listed for this medication. Always refer to your healthcare provider for personalized advice and guidance.

When taking this medication, some individuals may experience mild side effects such as nausea, headaches, decreased appetite, gas, and fever. These symptoms are common and generally not a cause for concern, but if they persist or worsen, it's advisable to consult a healthcare provider. Depression and swelling in the arms and legs have also been noted in some cases.

Occasionally, users might encounter other effects such as stomach pain or constipation. While these are typically manageable, severe cases of constipation or persistent abdominal pain should prompt immediate medical attention, as they might indicate more serious underlying issues.

Although it is rare, a very serious allergic reaction can occur. Warning signs include rash, itching, swelling (notably of the face, tongue, or throat), severe dizziness, and trouble breathing. These symptoms require urgent medical care to prevent further complications. Always remain vigilant and report any unusual or severe side effects to your healthcare provider.