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This medication comes with several important safety warnings and contraindications. It is crucial to review these carefully and discuss any concerns with your healthcare provider. Below are critical points to consider:

• Symptom Concealment Risk: Regular heartburn could indicate a more severe issue, such as stomach cancer. If symptoms worsen or return after using omeprazole (Prilosec), contact your healthcare provider. Be vigilant for additional symptoms like poor appetite, unexplained weight loss, or weakness.

• Kidney Concerns: Omeprazole (Prilosec) may cause sudden kidney issues, potentially at any stage of treatment. Seek medical advice if you notice changes in urination, nausea, weakness, fever, rash, or joint pain.

• Severe Diarrhea Risk: There is an increased risk of severe diarrhea due to Clostridioides difficile infection when using PPIs. The risk is higher for individuals over 65, those with recent hospital or nursing home stays, or those with a weakened immune system. Use the lowest effective dose for the shortest period and consult a provider if severe diarrhea or other symptoms occur.

• Bone Fracture Warning: Long-term or high-dose use of omeprazole (Prilosec) can raise the likelihood of fractures, especially in the hip, wrist, or spine. Discuss your risk with a healthcare provider, particularly if you have osteoporosis or a history of fractures.

• Skin Reactions: Rare but serious skin reactions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis, can occur. Immediate medical attention is required if symptoms like fever, rash, or blisters appear.

• Lupus Risk: Omeprazole (Prilosec) may cause new or worsening lupus symptoms. If symptoms such as joint pain or rash develop, discontinue use and seek medical advice.

• Deficiency Concerns: Prolonged use of this medication can lead to low vitamin B12 and magnesium levels. If you have been using it for over three years or show deficiency symptoms, consult your healthcare provider.

• Drug Interactions: Some drugs can alter the effectiveness of omeprazole (Prilosec), such as St. John’s wort and rifampin. Avoid these while on omeprazole (Prilosec).

• Lab Interference: Omeprazole (Prilosec) may affect certain medical tests, leading to inaccurate results. Inform your healthcare team of your medication use before undergoing tests.

Contraindications:

• Individuals with a known allergy to PPIs should not take this medication.
• Avoid use if you are receiving Edurant (rilpivirine) or any rilpivirine-containing medications.

Always consult your healthcare provider for personalized guidance and to ensure this medication is safe for your specific health needs.

Common side effects:

• Headache
• Abdominal pain
• Nausea
• Diarrhea
• Vomiting
• Passing gas

Less common but important to monitor:

• Respiratory system issues
• Fever
• Ear infections

Serious side effects:

• Muscle spasms
• Irregular heartbeat
• Seizures
• Signs of lupus (rash on the nose and cheeks or joint pain)
• Symptoms of kidney problems (changes in urine output or blood in urine)
• Severe intestinal condition caused by C. difficile (persistent diarrhea, stomach pain, and blood or mucus in stool)
• Vitamin B-12 deficiency (unusual weakness, sore tongue, or numbness in the hands or feet)
• Severe allergic reactions (fever, swollen lymph nodes, rash, swelling, severe dizziness, or trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Rilpivirine

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Clopidogrel
• Methotrexate
• Nelfinavir
• Atazanavir
• Erlotinib
• Levoketoconazole
• Pazopanib
• Itraconazole
• Ketoconazole
• Posaconazole
• Abametapir
• Acalabrutinib
• Amphetamine
• Benzphetamine
• Bosutinib
• Capecitabine
• Cilostazol
• Citalopram
• Clorazepate
• Conivaptan
• Dacomitinib
• Dasabuvir
• Dasatinib
• Delavirdine
• Dextroamphetamine
• Elagolix
• Escitalopram
• Eslicarbazepine Acetate
• Fosnetupitant
• Gefitinib
• Indinavir
• Ledipasvir
• Lisdexamfetamine
• Methamphetamine
• Mycophenolate Mofetil
• Neratinib
• Netupitant
• Nilotinib
• Octreotide
• Ombitasvir
• Paritaprevir
• Pexidartinib
• Ritonavir
• Saquinavir
• Secretin Human
• Selpercatinib
• Sunitinib
• Tacrolimus
• Velpatasvir
• Vismodegib
• Voriconazole

Interactions with low risk that usually do not require a change in therapy:

• Armodafinil
• Carbamazepine
• Digoxin
• St John's Wort
• Ginkgo Biloba
• Iron
• Levothyroxine
• Raltegravir
• Tipranavir
• Triazolam
• Warfarin